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https://www.matreya.com/search.aspx?keyword=1048
The metabolism of inositol lipids is involved in the signal transduction of many hormones, neurotransmitters and growth factors.1,2,3 In the classical pathway, phosphatidylinositol-specific phospholipase C (PI-PLC) hydrolyzes phosphatidyl 4,5- bisphosphate (PIP2) to yield 1,2-diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). The role of IP3 and DAG as second messengers is well recognized. In a second, more recently discovered pathway, the activation of phosphoinositide 3- kinase results in the formation of three novel phosphatidyl (PI) lipids phosphorylated at the D3 positions of the inositol ring: PI-3-P, PI-3,4-P2, and PI-3,4,5-P3. These D3 lipids are not known substrates for any of the phospholipase C enzymes and function as second messengers. PI 3-kinase activity is correlated with many cellular processes including the regulation of cell growth, oncogenic transformation, chemotaxis and receptor down-regulation. A recent paper on the effect of PI-3,4-P2 on the Akt proto-oncogene product also contains protocols for applying PIP’s to cell cultures.4 Matreya’s synthetic phosphatidylinositols and inositol phosphates are excellent tools for investigating these second messengers, understanding the enzyme mechanisms involved in phosphoinositide metabolism and designing therapeutic pharmacological agents.
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名称: 深圳市明博林生物科技有限公司 税务登记号 9144030055718808X9 地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A 电话: 0755-25106053 开户银行: 中国工商银行深圳红宝支行 账号: 4000024839200103206
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