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N-Dodecanoyl-NBD-sphingosylphosphorylcholine is a semisynthetic sphingomyelin containing the 7-(4-nitrobenzo-2-oxa-1, 3-diazole) (NBD) fluorescent group. NBD has been shown to have only a small influence on lipid adsorption into cells and cellular membranes in many applications. This fluorescent analog of natural sphingomyelin is comparable to C12:0- sphingomyelin in some biological functions.1 Sphingomyelin is found in mammalian cell membranes, especially in the membranes of the myelin sheath. It is the most abundant sphingolipid in mammals and is thought to be found mostly in the exoplasmic leaflet of the membrane although there is also evidence of a sphingomyelin pool in the inner leaflet of the membrane. It is involved in signal transduction and apoptosis. An improper ratio of sphingomyelin to ceramide has been shown to be a factor in Niemann-Pick disease and neonatal respiratory distress syndrome.2 However, the ratio of sphingomyelin to ceramide is different for different cell types.3 Sphingomyelin is an important amphiphilic component when plasma lipoprotein pools expand in response to large lipid loads or metabolic abnormalities.4 In contrast to ceramides Nhexanoyl- sphingosylphosphorylcholine does not initiate vesicle formation in cells. N-hexanoyl-sphingosylphosphorylcholine has been used to enhance the uptake of anti-tumor drugs by cancer cells, thereby increasing the cytotoxicity towards those cancer cells.5

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名称: 深圳市明博林生物科技有限公司
税务登记号 9144030055718808X9
地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A
电话: 0755-25106053
开户银行: 中国工商银行深圳红宝支行
账号: 4000024839200103206

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