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https://www.matreya.com/search.aspx?keyword=1891
3-keto-Dihydrosphingosine is a vital intermediate in the biosynthesis of ceramides.1,2 This lyso-sphingolipid is formed by the condensation of L-serine and palmitoyl-CoA by the serine palmitoyl transferase enzyme.3 It is then reduced to dihydrosphingosine, converted to ceramide, and eventually synthesized into many types of sphingolipids. C18-ketodihydrosphingosine is the major sphingolipid precursor in the early and intermediate stages of cell life with C20-ketodihydrosphingosine as a minor component. Towards the end of the cell’s life the ratio of C18 to C20 ketodihydrosphingosine becomes more equal. It is a critical regulating step in the availability of sphingolipids in cells. Vitamin K deficiency results in the inactivation of the serine palmitoyl transferase enzyme causing a resultant shortage of sphingolipids. Short-chain analogs of 3-keto-dihydrosphingosine have different physical properties from the long-chain 3- keto-dihydrosphingosines. Short-chain bases are considerably less hydrophobic which could significantly change the process of signal transduction.
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名称: 深圳市明博林生物科技有限公司 税务登记号 9144030055718808X9 地址: 深圳市龙岗区布吉大芬村茂业城怡和楼2座8A 电话: 0755-25106053 开户银行: 中国工商银行深圳红宝支行 账号: 4000024839200103206
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